Researchers report on a genome-wide reconstruction of human microbes to develop personalized therapies Natureportfolio uniofgalway GenomeWide Reconstruction HumanMicrobes PersonalizedTherapy PersonalizedMedicine
By Pooja Toshniwal PahariaJan 26 2023Reviewed by Aimee Molineux In a recent study published in Nature Biotechnology, researchers reported on AGORA2, an expansion of their previously published resource, AGORA, both resources of genomewide metabolic reconstructions of human intestinal microbes.
Newly reconstructed microbes were selected, and their full-genomic sequences of 4,185 human intestine microbial strains were retrieved from the PubSEED database. In addition, 1,324 microbial strains across 127.0 genomes of mice-related strains identified from a literature search were included. Moreover, 26.0 genomes of the strains of Eggerthella lenta, retrieved from the national center for biotechnology information database, and 761.0 human microbiota genomes available in HBC were included.
Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Atom-atom mapping analysis was performed for 5,583 reactions captured, and molecular simulations were performed. Seventy-two fully manually designed reconstructions were downloaded from the BiGG database, and reconstructions were generated.
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