Scientists investigate the evolutionary origin of SARS-CoV-2 using recombination-aware phylogenetic analysis researchsquare maxplanckpress SARSCoV2 COVID19 coronavirus covid evolution phylogenetics
By Dr. Priyom Bose, Ph.D.Nov 25 2022Reviewed by Danielle Ellis, B.Sc. Severe acute respiratory syndrome coronavirus 2 and severe acute respiratory syndrome coronavirus are members of the subgenus Sarbecovirus, whose genomic length is around 30,000 base pairs. These viruses encode four structural proteins, namely spike , envelope , membrane , and nucleocapsid .
Similar to coronaviruses, Sarbecoviruses are highly recombinant, and analysis of the SARS-CoV-2 RBD sequence indicated its origin involves genetic recombination. Out of four key hypotheses on the origin of SARS-CoV-2, three include recombination. About the study A study currently posted on the Research Square* preprint server while under consideration for publication in Scientific Reports has employed Bacter to identify recombination events with the RBD regions of the Sarbecovirus genome. The main aim of this study is to determine the origin of the amino acids located in the RBD's variable loop, which is responsible for the high affinity of SARS-CoV-2 to the ACE2 receptors of human cells.
Three Rhinolophus species showed overlapping geographical ranges, namely, R. pusillus, R, sinicus, and R. affinis. However, R. affinis and R. pusillus were proposed to be the possible hosts of SARS-CoV-2 progenitors.
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