Stem cell model of human brain development suggests embryonic origins of Alzheimer'sdisease ISSCR
is a highly prevalent, debilitating, and potentially fatal neurodegenerative disease with limited treatment options. Patients are typically diagnosed at an advanced disease stage, limiting the possibilities for early therapeutic intervention.
The researchers grew so-called cortical spheres, which are small clumps of cells resembling human embryonic brains, from CRISPR-edited stem cell lines harboring fAD mutations. Intriguingly, AD mutations interfered with normal development of these cortical spheres, whereby mutant spheres were larger and contained less mature and functioning neurons compared to cortical spheres without the mutations.
By pinpointing the underlying molecular pathways, the researchers could identify points of intervention to restore normal brain development in their cortical sphere model. Interestingly different types of AD-associated caused distinct developmental abnormalities in the cortical spheres, highlighting the need for tailoring therapies individually for each patient., paves the way for studying AD in its early stages with the possibility of identifying more effective or preventive treatments for AD in a patient-specific fashion.
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