Study finds Omicron variant could break through vaccine protection more effectively than the Delta variant medrxivpreprint SUNY Omicron vaccine COVID19 coronavirus covid Delta
By Pooja Toshniwal PahariaJun 29 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers assessed the efficacy of vaccinations against severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants of concern .
For the analysis, the New York State genomic sequence dataset was linked with the vaccination and demographic data of the participants. The adjusted associations of age, type of vaccination , the status of vaccination, and time elapsed since vaccination with SARS-CoV-2 strains were evaluated using odds ratios . Data were analyzed using logistic regression models of the Delta wave and Omicron wave, and the best fit models were decided using the Akaike information criterion scoring system.
Delta emergence analysis was performed between March 19, 2021, and August 15, 2021, for which cases comprised individuals infected with Delta , and those affected with any other SARS-CoV-2 strain except Delta during the Delta predominance period were considered as controls . Booster vaccination-associated variables were excluded from the Delta emergence analysis since booster doses were not readily available during this period.
On limiting the analysis to only individuals who were vaccinated, the likelihood of Omicron infections reduced with increases in the time elapsed since the last vaccination . Further, the likelihood of Omicron infections was lower with Janssen vaccinations compared to Pfizer vaccinations; in relation to any messenger ribonucleic acid vaccination.
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