Tasmanian devil analysis challenges study suggesting facial tumour disease decline

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Tasmanian devil analysis challenges study suggesting facial tumour disease decline
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Cambridge scientists critique research that concluded the disease is no longer a threat to the species’ survival

Cambridge researchers have challenged a previous study finding that a facial cancer that devastated the Tasmanian devil population was on the decline.

Elizabeth Murchison, a professor of comparative oncology and genetics at the University of Cambridge and one of the critique’s senior authors, saidShe said it was recommended that scientists sequence DNA at least 30 times when analysing tumours to have confidence that a variant is actually a mutation. Her reanalysis found the researchers in the original study sequenced DNA an average of 15 times.

The authors of the initial study disagreed, and said they stood by their research. They said they had published papers in the years since that “support the basic conclusion that continued survival of Tasmanian devils in the wild is likely and that there has been rapid evolution of devils in response to the disease”.

The Cambridge researchers said they reproduced the initial study after noticing that the tree mapping out how the tumour evolved over time generated by the original researchers “looked nothing” like their own tree.

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