Genomic screening can help detect thyroidcancer, finds study geisingerhealth JAMAOto
proto-oncogene variants associated with the risk of MTC via a population genomic screening program.This retrospective cross-sectional study was completed between June 1, 2016, and May 31, 2022, for a mean follow-up period of 22.4 months . The study included patients who were identified as having P/LPvariants through a population genomic screening program at a rural tertiary care center and who underwent thyroidectomy after results disclosure.
Twenty of these patients underwent total thyroidectomy; 13 of these patients also had a central neck dissection. No patients had clinically apparent disease at the time of surgery. Pathologic findings indicated MTC for 12 patients and papillary thyroid carcinoma in 2. Of patients with MTC, 10 had stage I disease, 1 had stage II disease, 1 had stage III disease, and none had stage IV disease.
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