Y chromosome loss with age is a major killer in men, but there may be a cure.
, the discovery might provide some insight into why males typically pass away at a younger age than women.the director of UVA's Hematovascular Biology Center,
"Particularly past age 60, men die more rapidly than women. It's as if they biologically age more quickly," explained Walsh."There are more than 160 million males in the United States alone. The years of life lost due to the survival disadvantage of maleness are staggering. This new research provides clues as to why men have shorter lifespans than women," he added.
Walsh, of UVA's Division of Cardiovascular Medicine and the Robert M. Berne Cardiovascular Research Center, and his research group created a unique mouse model to better study the impact of Y chromosome deletion in the blood using cutting-edgeThey discovered the loss hastened age-related disorders, increased the mice's susceptibility to cardiac scarring, and accelerated their mortality. The investigators found that this wasn't only an inflammatory response.
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