Cellular messengers improve cancer therapy
Extracellular vesicles are important mediators of intercellular communication and are potential candidates for cancer immunotherapy. Immune checkpoint blockade, specifically of the PD-1/PD-L1 axis, mitigates T cell exhaustion, but is only effective in a subset of cancer patients. Reasons for therapy resistance include low primary T-cell activation to cancer antigens, poor antigen presentation, and reduced T-cell infiltration into the tumor.
Here, we investigated whether EV therapy could induce susceptibility to anti-PD-1 or –PD-L1 therapy in a checkpoint-refractory B16 melanoma model. Injection of dendritic cell -derived EVs, but not checkpoint blockade induced a potent antigen-specific T cell response and reduced tumor growth in tumor-bearing mice. Combination therapy of EVs and anti-PD-1 or –PD-L1 potentiated immune responses to OVA- and α-galactosylceramide-loaded EVs in the therapeutic model.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Enamel biomineralization under the effects of indomethacin and celecoxib non-steroidal anti-inflammatory drugs - Scientific ReportsScientific Reports - Enamel biomineralization under the effects of indomethacin and celecoxib non-steroidal anti-inflammatory drugs
Read more »
Thales: Belfast missile-making firm awarded £223m contractBelfast missile-making firm Thales has been awarded a £223m contract to manufacture anti-tank missiles of the type sent by the UK to Ukraine.
Read more »
Belfast weapons factory gets anti-tank missile contractThe NLAW has played an important role in Ukraine’s defence capacities, making up part of the 10,000 anti-tank weapons the United Kingdom has supplied to the Ukrainian armed forces.
Read more »
Beresford Square revamp planned by Greenwich CouncilGreenwich Council wants to reduce anti-social behaviour in the square by increasing footfall.
Read more »
Characterization of anti-orthopoxvirus antibody response in general population and gay menCharacterization of anti-orthopoxvirus antibody response in general population and gay men medrxivpreprint OrthopoxVirus Mpox MpoxVIrus AntibodyResponse
Read more »
Dwayne Johnson says Black Adam will not be part of new DC UniverseActor Dwayne 'The Rock' Johnson has revealed that his anti-hero Black Adam from DC's film of the same name will not feature in the newly restructured DC universe
Read more »