Bioinformatics analysis of monkeypox virus-host cell interactions Bioinformatics Cell Monkeypox Virus Bioinformatics biorxivpreprint CSU_China
By Dr. Priyom Bose, Ph.D.Oct 18 2022Reviewed by Emily Henderson, B.Sc. Although monkeypox virus infection was predominantly found in West and Central Africa, since May 2022, this double-stranded DNA virus has been reported in many countries outside Africa. Similar to the smallpox virus, the monkeypox virus also belongs to the orthopoxvirus family and is less severe. The World Health Organization recently declared the global monkeypox outbreak a public health emergency of international concern.
Two main routes for disease transmission are animal-to-human transmission and human-to-human transmission. Recent monkeypox outbreak-related studies have reported transmission through MSM . Study Findings A total of 84 DEGs, except histone genes, were found, which were used for further studies. Viral interactions rely heavily on early genes to infect host cells, ensuring their survival, replication, and transmission. These genes are also associated with the regulation of host immunity. Therefore, the gene expression status of the monkeypox virus was analyzed, and 26 suspected early genes were detected, which encoded for the ankyrin repeat protein.
Genetic disease analysis was conducted to predict the relationship between monkeypox DEGs and different diseases. This analysis revealed the association of monkeypox infection with liver cirrhosis, reperfusion injury, mammary neoplasms, inflammation, hypertensive disease, juvenile arthritis, and brain ischemia. The findings of this study were consistent with previous reports that revealed complications and sequelae of monkeypox.
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