How effective are prior SARS-CoV-2 infections and hybrid immunity against Omicron breakthrough infections? UofT SARSCoV2 COVID19 Infections HybridImmunity Omicron Breakthrough
By Neha MathurJan 20 2023Reviewed by Aimee Molineux In a recent article published in Lancet Infectious Diseases, researchers performed a systematic review and meta-regression study to determine the breadth and duration of the protective immunity conferred by previous severe acute respiratory syndrome coronavirus 2 infection and hybrid immunity. They evaluated this data evidence against SARS-CoV-2 Omicron-caused infection.
The researchers assessed several outcomes related to hybrid immunity, such as hybrid immunity relative to previous infection alone, vaccination alone, and hybrid immunity with fewer vaccine doses. They also determined the risk of bias in the studies covered in the study analysis. Additionally, they used log-odds random-effects meta-regression to estimate the breadth of immune protection against Omicron at one-month intervals throughout the study duration.
Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Since infection-induced protection against breakthrough infection wanes quickly and vaccination upturns the durability of this protection; therefore, vaccination is a reliable intervention to thwart severe COVID-19 outcomes and reduce post-COVID-19 complications, including cardiovascular and neurological sequelae.
In such countries, they could identify individuals as infected before with an anti-nucleocapsid diagnostic assay to inform recommendations for boosters. This approach, however, does not apply to high-risk groups .
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